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Systematic reviewers have had variable success in contacting trialists, clinicians, and sponsors for information about unpublished trials.4 22 23 24 25 Efforts to obtain full trial protocols from trialists have been largely disappointing.26 27 On the other hand, surveys soliciting information on the existence and statistical significance of unreported outcomes for published trials have had higher response rates from trialists.28 29 These surveys have also yielded information about the reasons for changing or omitting trial outcomes.

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Under the most likely scenarios for the WHO negotiations, the United States would have no new obligations to fund R but other countries would. government already does through the NIH and other federal agencies. Because the pharmaceutical industry perceives a binding R funding agreement as a competing international paradigm for the trade related aspects of R and one that is potentially a substitute for the current paradigm of trade pressures forcing strong IPR and high drug prices, they lobbied the DHHS to kill or block the R funding discussions.

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